Disc4All Publications

  • Towards Self‐Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture

    Bournonville, S. et al.

    Biotechnol. J. 14, 1800545

  • TRPC6 in simulated microgravity of intervertebral disc cells

    Franco-Obregón A, Cambria E, Greutert H, Wernas T, Egli M, Sekiguchi M, Boos N, Hausmann ON, Ferguson SJ, Kobayashi H, Wuertz-Kozak K

    Eur Spine J., 2018 Oct;27(10):2621-2630

  • p38 MAPK facilitates crosstalk between endoplasmic reticulum stress and IL-6 release in the intervertebral disc

    Krupkova O, Sadowska A, Kameda T, Hausmann O, Klasen J, Wuertz-Kozak K

    Frontiers in Immunology, 2018 Aug 17;9:1706

  • A photopolymerized Poly-Ethlyene-Glycol composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

    Schmocker AM, Khoushabi A, Frauchiger DA, Gantenbein B, Schizas C, Moser C, Bourban P-E, Pioletti D

    Biomaterials 88110-119 doi: 10.1016/j.biomaterials.2016.02.015.

  • Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells

    Tekari, A., Chan, S. C. W., Sakai, D., Grad, S., & Gantenbein, B.

    Stem Cell Res Ther, 7(1), 75

  • Osteogenic differentiation of bone marrow stromal cells is hindered by the presence of intervertebral disc cells

    Chan, S. C. W., Tekari, A., Benneker, L. M., Heini, P. F., & Gantenbein, B

    Arthritis Res Ther, 18(1), 29

  • Potential Roles of Cytokines and Chemokines in Human Intervertebral Disc Degeneration: Interleukin-1 is a Master Regulator of catabolic processes

    Phillips KLE, Chiverton N, Michael ALR, Cole AA, Breakwell LM, Haddock G, Bunning RAD, Cross AK, Le Maitre CL

    Osteoarthritis and cartilage. 23(7):1165-77

  • Organ Culture Bioreactors – Platforms to Study Human Intervertebral Disc Degeneration and Regenerative Therapy

    Gantenbein B, Illien-Jünger S, Chan SC, Walser J, Haglund L, Ferguson SJ, Iatridis JC, Grad S

    Curr Stem Cell Res Ther 10(4):339-352

  • Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration

    Binch ALA, Cole AA, Breakwell LM, Michael ALR, Chiverton N, Cross AK, Le Maitre CL

    Arthritis Research and Therapy. 16(5): 416

  • Region specific response of the intervertebral disc cells to complex dynamic loading (2013) An organ culture study using a bi-axial loading bioreactor

    Chan SC, Walser J, Käppeli P, Shamsollahi M, Ferguson SJ, Gantenbein-Ritter B

    PLoS ONE 2013; 8:e72489

  • Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain

    Wuertz, K. & Haglund, L

    Glob. Spine J. 3, 175–184

  • The Cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the Intervertebral disc

    Phillips KLE, Chiverton N, Michael ALR, Cole AA, Breakwell LM, Haddock G, Bunning RAD, Cross AK, Le Maitre CL

    Arthritis Research and Therapy. 15: R213

  • In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression

    Wuertz K, Godburn K, MacLean JJ, Barbir A, Donnelly JS, Roughley PJ, Alini M, Iatridis JC

    J Orthop Res. 2009 Sep;27(9):1235-42

  • Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs

    Le Maitre, C. L. et al

    Arthritis Rheum. 60, 460–469

  • The Role of Interleukin 1 (IL-1) in the pathogenesis of human Intervertebral disc (IVD) degeneration

    Le Maitre CL, Freemont AJ, Hoyland JA

    Arthritis Research and Therapy.7: R732-R745