Disc4All Publications

  • In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation

    Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitree, Janet Piñeroh, Baldomero Oliva, Benjamin Gantenbein

  • Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue Such as Intervertebral Disc Using QuPath

    Andrea Nüesch, Maria Paola Ferri, Christine L. Le Maitre

    https://onlinelibrary.wiley.com/doi/10.1002/jsp2.70054

  • Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology

    Paola Bermudez-Lekerika, Sofia Tseranidou, Exarchos Kanelis, Andrea Nüesch, Katherine B. Crump, Leonidas G. Alexopoulos, Karin Wuertz-Kozak, Jérôme Noailly, Christine L. Le Maitre, Benjamin Gantenbein

  • A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc

    Dimitrios Lialios, Beatriz Eguzkitza, Guillaume Houzeaux, Eva Casoni, Laura Baumgartner, Jérôme Noailly, Estefano Muñoz-Moya, Benjamin Gantenbein, Mariano Vázquez

  • Nucleus pulposus cell network modelling in the intervertebral disc

    Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion, Christine Le Maitre, Janet Piñero & Jérôme Noailly

  • The Role of the Bone Morphogenetic Protein Antagonist Noggin in Nucleus Pulposus Intervertebral Disc Cells

    Shuimu Chen, Sebastian Bigdon,Carsten Riether, Xiaochi Ma, Xiaoyi Niu, Sonja Häckel, Zhen Li and Benjamin Gantenbein

  • Domain adaptation using AdaBN and AdaIN for high-resolution IVD mesh reconstruction from clinical MRI

    Sai Natarajan, Ludovic Humbert & Miguel A. González Ballester

  • PREDICTING GENE DISEASE ASSOCIATIONS WITH KNOWLEDGE GRAPH EMBEDDINGS FOR DISEASES WITH CURTAILED INFORMATION

    Francesco Gualdi, Baldomero Oliva, Janet Piñero

  • Unveiling interactions between intervertebral disc morphologies and mechanical behavior through personalized finite element modeling

    Estefano Muñoz-Moya, Morteza Rasouligandomani, Carlos Ruiz Wills, Francis Kiptengwer Chemorion, Gemma Piella, Jérôme Noailly

  • Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems

    Paola Bermudez-Lekerika, Katherine B. Crump, Karin Wuertz-Kozak, Christine L. Le Maitre, Benjamin Gantenbein

  • Are current machine learning applications comparable to radiologist classification of degenerate and herniated discs and Modic change? A systematic review and meta-analysis.

    Roger Compte, Isabelle Granville Smith, Amanda Isaac, Nathan Danckert, Terence McSweeney, Panagiotis Liantis, Frances M K Williams

  • No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins

    Abstract Introduction Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.

    Roger Compte, Maxim B. Freidin, Isabelle Granville Smith, Christine L. Le Maitre, Dovile Vaitkute, Ayrun Nessa, Genevieve Lachance, Frances M. K. Williams

  • PREDICTING GENE DISEASE ASSOCIATIONS WITH KNOWLEDGE GRAPH EMBEDDINGS FOR DISEASES WITH CURTAILED INFORMATION

    Francesco Gualdi, Baldomero Oliva, Janet Piñero

  • Semi-automatic Assessment of Facet Tropism from Lumbar Spine MRI using Deep Learning: A Northern Finland Birth Cohort Study

    Kowlagi, Narasimharao Msca; Kemppainen, Antti PhDb; Panfilov, Egor Msca; McSweeney, Terence MSca; Saarakkala, Simo PhDa,b; Nevalainen, Mika MD, PhDa,b; Niinimäki, Jaakko MD, PhDb; Karppinen, Jaro MD, PhDa,c; Tiulpin, Aleksei PhDa,d

  • The Interplay between Biochemical Mediators and Mechanotransduction in Chondrocytes: Unravelling the Differential Responses in Primary Knee Osteoarthritis

    Maria Segarra-Queralt, Katherine Crump, Andreu Pascuet-Fontanet, Benjamin Gantenbein, Jérôme Noailly

  • Cartilaginous endplates: A comprehensive review on aneglected structure in intervertebral disc research

    Katherine B. Crump, Ahmad Alminnawi, Paola Bermudez-Lekerika, Roger Compte, Francesco Gualdi, Terence McSweeney, Estefano Muñoz-Moya, Andrea Nüesch, Liesbet Geris, Stefan Dudli, Jaro Karppinen, Jérôme Noailly, Christine Le Maitre, Benjamin Gantenbein

  • Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK

    Francesco Gualdi, Isabelle Granville Smith, Roger Compte Boixader & Frances M. K. Williams

  • Proximal Junction Failure in Spine Surgery: Integrating Geometrical and Biomechanical Global Descriptors Improves GAP Score-Based Assessment

  • External Validation of SpineNet, an Open-Source Deep Learning Model for Grading Lumbar Disk Degeneration MRI Features, Using the Northern Finland Birth Cohort 1966

    McSweeney, Terence P. MSca,b; Tiulpin, Aleksei PhDa,b; Saarakkala, Simo PhDa,b,c; Niinimäki, Jaakko MD, PhDa,b,c; Windsor, Rhydian MScd; Jamaludin, Amir PhDd; Kadir, Timor PhDd,e; Karppinen, Jaro MD, PhDa,b,f; Määttä, Juhani MD, PhD

  • Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells

    Adel Tekari, Alessandro Marazza, Katherine Crump, Paola Bermudez-Lekerika, Benjamin Gantenbein

  • Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

    Emily Lazarus, Paola Bermudez-Lekerika, Daniel Farchione, Taylor Schofield, Sloan Howard, Iskender Mambetkadyrov, Mikkael Lamoca, Iris V. Rivero, Benjamin Gantenbein, Christopher L. Lewis, Karin Wuertz-Kozak

  • Evidence-Based Network Modelling to Simulate Nucleus Pulposus Multicellular Activity in Different Nutritional and Pro-Inflammatory Environments

    L. Baumgartner, A. Sadowska, L , M. A. González Ballester, K. Wuertz-Kozak and J. Noailly

  • Non-viral Gene Delivery Methods for Bone and Joints

    Gantenbein B, Tang S, Guerrero J, Higuita-Castro N, Salazar-Puerta AI, Croft AS, Gazdhar A, Purmessur D

    Front Bioeng Biotechnol 8: 1320

  • EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs

    Gantenbein B, May RD, Bermudez-Lekerika P, Oswald KAC, Benneker LM, Albers CE

    Applied Sciences 11(9)

  • Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

    Baumgartner, L. et al.

    Int. J. Mol. Sci. 22, 703

  • Simulating intervertebral disc cell behaviour within 3D multifactorial environments. Bioinformatics

    Baumgartner, L., Reagh, J. J., González Ballester, M. A. & Noailly, J.