Disc4All Publications


    Francesco Gualdi, Baldomero Oliva, Janet Piñero

  • Unveiling interactions between intervertebral disc morphologies and mechanical behavior through personalized finite element modeling

    Estefano Muñoz-Moya, Morteza Rasouligandomani, Carlos Ruiz Wills, Francis Kiptengwer Chemorion, Gemma Piella, Jérôme Noailly

  • Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems

    Paola Bermudez-Lekerika, Katherine B. Crump, Karin Wuertz-Kozak, Christine L. Le Maitre, Benjamin Gantenbein

  • No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins

    Abstract Introduction Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.

    Roger Compte, Maxim B. Freidin, Isabelle Granville Smith, Christine L. Le Maitre, Dovile Vaitkute, Ayrun Nessa, Genevieve Lachance, Frances M. K. Williams


    Francesco Gualdi, Baldomero Oliva, Janet Piñero

  • Semi-automatic Assessment of Facet Tropism from Lumbar Spine MRI using Deep Learning: A Northern Finland Birth Cohort Study

    Kowlagi, Narasimharao Msca; Kemppainen, Antti PhDb; Panfilov, Egor Msca; McSweeney, Terence MSca; Saarakkala, Simo PhDa,b; Nevalainen, Mika MD, PhDa,b; Niinimäki, Jaakko MD, PhDb; Karppinen, Jaro MD, PhDa,c; Tiulpin, Aleksei PhDa,d

  • The Interplay between Biochemical Mediators and Mechanotransduction in Chondrocytes: Unravelling the Differential Responses in Primary Knee Osteoarthritis

    Maria Segarra-Queralt, Katherine Crump, Andreu Pascuet-Fontanet, Benjamin Gantenbein, Jérôme Noailly

  • Cartilaginous endplates: A comprehensive review on aneglected structure in intervertebral disc research

    Katherine B. Crump, Ahmad Alminnawi, Paola Bermudez-Lekerika, Roger Compte, Francesco Gualdi, Terence McSweeney, Estefano Muñoz-Moya, Andrea Nüesch, Liesbet Geris, Stefan Dudli, Jaro Karppinen, Jérôme Noailly, Christine Le Maitre, Benjamin Gantenbein

  • Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK

    Francesco Gualdi, Isabelle Granville Smith, Roger Compte Boixader & Frances M. K. Williams

  • Proximal Junction Failure in Spine Surgery: Integrating Geometrical and Biomechanical Global Descriptors Improves GAP Score-Based Assessment

  • External Validation of SpineNet, an Open-Source Deep Learning Model for Grading Lumbar Disk Degeneration MRI Features, Using the Northern Finland Birth Cohort 1966

    McSweeney, Terence P. MSca,b; Tiulpin, Aleksei PhDa,b; Saarakkala, Simo PhDa,b,c; Niinimäki, Jaakko MD, PhDa,b,c; Windsor, Rhydian MScd; Jamaludin, Amir PhDd; Kadir, Timor PhDd,e; Karppinen, Jaro MD, PhDa,b,f; Määttä, Juhani MD, PhD

  • Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells

    Adel Tekari, Alessandro Marazza, Katherine Crump, Paola Bermudez-Lekerika, Benjamin Gantenbein

  • Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

    Emily Lazarus, Paola Bermudez-Lekerika, Daniel Farchione, Taylor Schofield, Sloan Howard, Iskender Mambetkadyrov, Mikkael Lamoca, Iris V. Rivero, Benjamin Gantenbein, Christopher L. Lewis, Karin Wuertz-Kozak

  • Evidence-Based Network Modelling to Simulate Nucleus Pulposus Multicellular Activity in Different Nutritional and Pro-Inflammatory Environments

    L. Baumgartner, A. Sadowska, L , M. A. González Ballester, K. Wuertz-Kozak and J. Noailly

  • Non-viral Gene Delivery Methods for Bone and Joints

    Gantenbein B, Tang S, Guerrero J, Higuita-Castro N, Salazar-Puerta AI, Croft AS, Gazdhar A, Purmessur D

    Front Bioeng Biotechnol 8: 1320

  • EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs

    Gantenbein B, May RD, Bermudez-Lekerika P, Oswald KAC, Benneker LM, Albers CE

    Applied Sciences 11(9)

  • Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

    Baumgartner, L. et al.

    Int. J. Mol. Sci. 22, 703

  • Simulating intervertebral disc cell behaviour within 3D multifactorial environments. Bioinformatics

    Baumgartner, L., Reagh, J. J., González Ballester, M. A. & Noailly, J.